DHT – Dihydrotestosterone

Dihydrotestosterone (DHT) is an androgen, synthesized primarily in the male prostate gland, testes, hair follicles, and adrenal glands by the enzyme 5a-reductase. DHT has an important role in optimizing your over-all health and performance via the central nervous system, increasing strength, fighting against stress, and improving sexual function and libido.

Role of Testosterone and Dihydrotestosterone in Gynecomastia

September 10, 2010

Researchers in México examined the role of testosterone and dihydrotestosterone in the development of spontaneous gynecomastia in adolescents. They compared a group with pubertal spontaneous gynecomastia (PSG) and healthy young volunteers (HYV) to test a possible hormonal mechanism of gynecomastia at puberty.

The PSG group had an average testosterone (T) to dihydrotestosterone (DHT) ratio of 5.0 to 15.4, while the HYV group had a lower T:DHT ratio of 0.42 to 2.224.

The results led the researchers to two possible conclusions:

  1. Spontaneous gynecomastia might be caused by an enzimatic block of 5α-reductase (blocking the conversion of T to DHT);
  2. A decrease in the T:DHT ratio might favor the estrogen action for breast enlargement (aromatization of T to estriadol.)

This research was published in Systems Biology in Reproductive Medicine and was available in the Archives of Andrology. Read the full abstract here.

Topical DHT cream can address both of these possible causes. By applying DHT directly to the chest, you increase your DHT levels and compensate for the 5α-reductase block. Also, administration of DHT can lower testosterone production to be more in balance with estriadol, preventing aromatization and unwanted breast growth.

What is Gynecomastia?

Gynecomastia is a common disease of the male breast where there is a benign glandular enlargement of that breast at some time in the males life. It usually consists of the appearance of a flat pad of glandular tissue beneath a nipple which becomes tender at the same time. The development may be unilateral or bilateral. Find out more about Gynecomastia and how to treat it with DHT.

Effect of Dihydrotestosterone (DHT) on Prostate Tissue

August 9, 2010

In a recent study, researchers sought to understand the effects of Dihydrotestosterone (DHT) on the prostate gland to help in the development of safe treatments for low male hormone levels in men and prevention of diseases of the prostate. Subjects used topical DHT gel or a placebo gel (with no active drug in it).

The effect of DHT on the prostate is not clearly known. Some studies suggest blocking production of DHT in the prostate helps slow growth of the gland with aging (a condition known as benign prostatic hyperplasia, or BPH) and may prevent prostate cancer. On the other hand, DHT administration may shrink the prostate, suggesting DHT may be beneficial for some men. Therefore, further studies looking at the effect of DHT on the prostate are needed.

Read the complete clinical trial proposal.

DHT Gel Causes Dramatic Reductions in Gynecomastia Within 10-21 Days

August 7, 2010

Gynecomastia in men appears to be a problem associated with potent antiretroviral therapy, and is appearing more commonly since the introduction of protease inhibitor-based therapy. Two phenomena appear to occur: increased fat accumulation in the breast, or true gynecomastia with increased glandular tissue. Patients may be asymptomatic or may have discomfort or pain.

Management of gynecomastia is not well defined. Reversal does not always occur when specific drugs are discontinued or switched. Some patients have opted for gynecomastia surgery. An intriguing recent report studied the use of dihydrotestosterone gel applied to the skin. In this report, the investigators hypothesized that some component of the regimen might be mimicking the effect of estrogen on breast tissue. A total of 4 patients were treated with dihydrotestosterone gel and all had rapid and dramatic reductions in breast tissue within 10-21 days. The interesting response to dihydrotestosterone does suggest that other androgens or antiestrogens might be beneficial.

Read the full abstract here.

Discover the Solution to Male Menopause

July 7, 2010

Male MenopauseMale menopause (Andropause) is a term frequently used to describe a condition many middle aged men go through where libido and vigor slowly decrease.

One compelling new solution to male menopause is topical Dihydrotestosterone (DHT), available as DHT cream or DHT gel. An advantage DHT has over testosterone is that is doesn’t convert to estriadol as testosterone does.

“Anyone guy serious about keeping youthful libido through middle age and beyond should look into topical DHT. It’s incredibly effective at increasing libido and gives a general ’alpha male’ feeling of well being. Testosterone supplementation shut me down hard similar to what bodybuilders go through but topical DHT brought me back and I feel and perform great”.

Read the complete press release here.

Get Rid of Gynecomastia with DHT Gel

June 30, 2010

DHT Gel for GynecomastiaThere have been several successful studies that demonstrated the effectiveness of DHT gel in treating gynecomastia (male breast development.)

On study looked at forty adult men with persistent  gynaecomastia (of more than 18 months duration) being treated with local topical administration of DHT gel (125mg of DHT twice a day.) The patient’s DHT levels rose significantly, while both Testosterone and Estrogen levels dropped, and the breast tissue reduced in 29 of the subjects.

They concluded that regular DHT use is an efficient treatment for gynaecomastia due principally to the increase in DHT levels and a decrease in testicular E2 and T secretion following a reduction in LH secretion.

Read the full abstract here.

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